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Drug-induced angioedema is a known complication of the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969. [ 1 ] : 120 The angioedema appears to be dose dependent as it may resolve with decreased dose.
ACE inhibitors have also been shown to cause a central enhancement of parasympathetic nervous system activity in healthy volunteers and patients with heart failure. [ 48 ] [ 49 ] This action may reduce the prevalence of malignant cardiac arrhythmias, and the reduction in sudden death reported in large clinical trials. [ 50 ]
Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema. [2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe. [3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity. [2] Benazepril was patented in 1981 and came into medical ...
Lisinopril is an ACE inhibitor, meaning it blocks the actions of angiotensin-converting enzyme (ACE) in the renin–angiotensin–aldosterone system (RAAS), preventing angiotensin I from being converted to angiotensin II. Angiotensin II is a potent direct vasoconstrictor and a stimulator of aldosterone release.
Serious side effects may include liver problems, low blood pressure, angioedema, kidney problems, and high blood potassium. [3] Use in pregnancy and breastfeeding is not recommended. [4] It is among a class of drugs called ACE inhibitors and works by decreasing renin-angiotensin-aldosterone system activity. [3]
ATC code C09 Agents acting on the renin–angiotensin system is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
The most serious common adverse event is angioedema (swelling) (0.68%) which often affects the face and lips, endangering the patient's airway. Angioedema can occur at any point during treatment with enalapril, but is most common after the first few doses. [3] Angioedema and fatality therefrom are reportedly higher among black people. [3]
While one of the main rationales for the use of this class is the avoidance of a persistent dry cough and/or angioedema associated with ACE inhibitor therapy, rarely they may still occur. In addition, there is also a small risk of cross-reactivity in patients having experienced angioedema with ACE inhibitor therapy. [18]
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