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Controlled-nitrogen-release technologies based on polymers derived from combining urea and formaldehyde were first produced in 1936 and commercialized in 1955. [3] The early product had 60 percent of the total nitrogen cold-water-insoluble, and the unreacted (quick-release) less than 15%.
The release technology scientific and industrial community is represented by the Controlled Release Society (CRS). The CRS is the worldwide society for delivery science and technologies. CRS serves more than 1,600 members from more than 50 countries.
Osmotic release systems have a number of major advantages over other controlled-release mechanisms. They are significantly less affected by factors such as pH, food intake, GI motility, and differing intestinal environments. Using an osmotic pump to deliver drugs has additional inherent advantages regarding control over drug delivery rates.
Gated drug delivery systems are a method of controlled drug release that center around the use of physical molecules that cover the pores of drug carriers until triggered for removal by an external stimulus. Gated drug delivery systems are a recent innovation in the field of drug delivery and pose as a promising candidate for future drug ...
Since the approval of the first controlled-release formulation in the 1950s, research into new delivery systems has been progressing, as opposed to new drug development which has been declining. [13] [14] [15] Several factors may be contributing to this shift in focus. One of the driving factors is the high cost of developing new drugs.
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...
The highly targeted and controlled release ability, as well as their broad applications, make pH-responsive drug delivery systems some of the most well-researched and sought after clinical solutions in stimuli-responsive drug delivery. [3]
MNPs offer the advantage of controlled release of medication and simple application without medical professional assistance required. [6] With advanced MNPs technology, drug delivery can be specified for local usage, for example skin whitener [7] MNPs that are applied to the face. Many types of MNPs have been developed to penetrate tissues ...