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  2. Protein kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Protein_kinase_inhibitor

    A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate , or PO 4 , group) to a protein and can modulate its function.

  3. List of antineoplastic agents - Wikipedia

    en.wikipedia.org/wiki/List_of_antineoplastic_agents

    Tyrosine kinase inhibitor (TKI) with selective activity against RET, VEGFR-2 and EGFR: Medullary thyroid cancer. Diarrhoea, hypertension, QT interval prolongation, depression, electrolyte anomalies, hypothyroidism and GI perforation (uncommon). 2.3 mTOR inhibitors: Everolimus: PO: mTOR inhibitor.

  4. Category:Kinase inhibitors - Wikipedia

    en.wikipedia.org/wiki/Category:Kinase_inhibitors

    Protein kinase inhibitors (4 C, 62 P) Pages in category "Kinase inhibitors" The following 16 pages are in this category, out of 16 total.

  5. Category:Protein kinase inhibitors - Wikipedia

    en.wikipedia.org/wiki/Category:Protein_kinase...

    Pages in category "Protein kinase inhibitors" The following 62 pages are in this category, out of 62 total. This list may not reflect recent changes. ...

  6. Ilunocitinib - Wikipedia

    en.wikipedia.org/wiki/Ilunocitinib

    Ilunocitinib, sold under the brand name Zenrelia, is a veterinary medication used for the treatment of pruritus (itching) in dogs. [1] [3] It is a non-selective janus kinase inhibitor. [3] Ilunocitinib was approved for medical use in the United States in September 2024, [4] and in Canada in December 2024. [1]

  7. Enzyme inhibitor - Wikipedia

    en.wikipedia.org/wiki/Enzyme_inhibitor

    As of 2017, an estimated 29% of approved drugs are enzyme inhibitors [96] of which approximately one-fifth are kinase inhibitors. [96] A notable class of kinase drug targets is the receptor tyrosine kinases which are essential enzymes that regulate cell growth; their over-activation may result in cancer. Hence kinase inhibitors such as imatinib ...

  8. Rho kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Rho_kinase_inhibitor

    A number of Rho kinase inhibitors are known. [15] [16] [17]Chemical structure of fasudil. AT-13148 [18]; BA-210; β-ElemeneBelumosudil; Chroman 1 [19] [20]; DJ4, which is a selective multi-specific ATP competitive inhibitor of activity of ROCK1 (IC50 of 5 nM), ROCK2 (IC50 of 50 nM), MRCKα (IC50 of 10 nM) and MRCKβ (IC50 of 100 nM) kinases without affecting activity of PAK1 and DMPK at 5 μM ...

  9. mTOR inhibitors - Wikipedia

    en.wikipedia.org/wiki/MTOR_inhibitors

    mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...