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However, the neurotoxic side effects occurring at the required dosages have prevented the widespread use of metronidazole as an adjuvant agent in radiation therapy. [32] However, other nitroimidazoles derived from metronidazole such as nimorazole with reduced electron affinity showed less serious neuronal side effects and have found their way ...
Benefits of topical metronidazole include its effectiveness in reducing symptoms, extensive clinical experience supporting its use, and generally good tolerability with minimal systemic side effects; still, some patients may experience mild local irritation upon initial use, and it may have limited impact on persistent facial redness (erythema).
PPIs may induce common side effects including headache, diarrhoea, abdominal pain, and nausea. Taking PPI may rarely cause community-acquired pneumonia . Prolonged use of PPI may be associated with intestinal Clostridioides difficile infection , low magnesium level , Vitamin B12 and iron deficiency, osteoporosis , acute kidney inflammation, and ...
These effects are known from the drug's components as well as from other antibiotics. A very rare but dangerous reaction is Stevens–Johnson syndrome , a life-threatening condition affecting the skin, which has also been described under metronidazole and tetracycline as separate drugs.
The evidence for comparing metronidazole to other alternatives such as mebendazole, tinidazole, or nitazoxanide was felt to be of very low quality. [60] While tinidazole has side effects and efficacy similar to those of metronidazole, it is administered with a single dose.
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For people who are symptomatic, it is used after treatment with metronidazole or tinidazole. [2] It is taken by mouth. [1] Diloxanide generally has mild side effects. [3] Side effects may include flatulence, vomiting, and itchiness. [1] During pregnancy it is recommended that it be taken after the first trimester. [1]
However, isotretinoin has potentially serious side effects, and few patients with seborrhoeic dermatitis are appropriate candidates for therapy. [26] Topical 0.75% and 1% Metronidazole [10] [11] Topical 4% nicotinamide [3] Topical sulfacetamide [11] Tea tree oil [12] Cannabidiol shampoo [24]
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