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Sleep-related hypermotor epilepsy (SHE), previously known as nocturnal frontal lobe epilepsy, is a form of focal epilepsy characterized by seizures which arise during sleep. The seizures are most typically characterized by complex motor behaviors. It is a relatively uncommon form of epilepsy that constitutes approximately 9-13% of cases.
Epilepsy is more common among children than adults, affecting about 6 out of 1000 US children that are between the age of 0 to 5 years old. [2] The epileptic seizures can be of different types depending on the part of the brain that was affected, seizures are classified in 2 main types partial seizure or generalized seizure .
Seizures originate in the occipital lobe and account for 5 to 10 percent of all epileptic seizure types. Generally, this type of epilepsy can have an onset anywhere from 1–17 years old in children, but the patient prognosis is good. Since the event is located in the occipital lobe, symptoms may occur spontaneously and include visual stimuli.
Panayiotopoulos syndrome (named after C. P. Panayiotopoulos) is a common idiopathic childhood-related seizure disorder that occurs exclusively in otherwise normal children (idiopathic epilepsy) and manifests mainly with autonomic epileptic seizures and autonomic status epilepticus. [1]
In addition to the abdominal pain and nausea/vomiting, other symptoms of seizures can sometimes be seen in abdominal epilepsy and may be helpful in diagnosis, including a duration of seconds to minutes, confusion or unresponsiveness during episodes, lethargy or sleep after episodes, and progression from abdominal aura into another type of seizure.
Abdominal epilepsy is marked by GI symptoms such as abdominal pain followed by uncontrollable vomiting, usually preceded by lethargy. Lethargy and confusion is the most common neurological symptoms associated with abdominal epilepsy. Other symptoms include generalized tonic-clonic seizures followed by sleep, and unresponsiveness.
Praxis Precision Medicines Inc (NASDAQ: PRAX) plans to start the PRAX-222 EMBRAVE study for pediatric patients with early-seizure-onset SCN2A developmental and epileptic encephalopathy (DEE).
Benign infantile epilepsy (BIE), also known as benign infantile seizures (BIS), is an epilepsy syndrome of which several forms have been described. The International League Against Epilepsy (ILAE) classify two main forms of the syndrome (familial and nonfamilial) [ 1 ] though several other forms have been described in the academic literature.
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