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Sulfasalazine metabolizes to sulfapyridine. Serum levels should be monitored every three months, and more frequently at the outset. Serum levels above 50 μg/L are associated with side effects. In rare cases, sulfasalazine can cause severe depression in young males. It can also cause oligospermia and temporary infertility.
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Sulfapyridine levels above 50 μg/L are associated with the side-effects. Patients on high dose sulfasalazine require folic supplementation (1 mg/day) (1000 μg/day) to maintain normal cell division. This may, however, be counter-productive for patients who are also taking methotrexate, which is a folic acid inhibitor.
Sulfasalazine; Mesalazine (5-Aminosalicylic acid) Side effects may include abdominal pain, diarrhea, headaches, and nausea. [1] References This page was last edited ...
Gastrointestinal side-effects (nausea, vomiting, diarrhoea) are common; the delayed-release formulation is meant to help overcome this problem. [15] It is also a cause of drug-induced hepatitis. Patients with glucose-6-phosphate dehydrogenase deficiency should avoid taking aminosalicylic acid as it causes haemolysis. [16]
It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra , which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis , and this, rather than the development of resistance by bacteria, is the main ...
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