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Serum (blood) - Wikipedia
Hereditary abnormalities of fibrinogen (the gene is carried on chromosome 4) are both quantitative and qualitative in nature and include afibrinogenaemia, hypofibrinogenaemia, dysfibrinogenaemia, and hypodysfibrinogenemia. Reduced, absent, or dysfunctional fibrin is likely to render patients as hemophiliacs.
In plasma or serum (g/cm 3) Water: Solvent 0.81-0.86 0.93-0.95 Acetoacetate: Produced in liver 8-40 × 10 −7: 4-43 × 10 −7: Acetone: product of bodyfat breakdown 3-20 × 10 −6: Acetylcholine: Neurotransmitter of the parasympathetic nervous system: 6.6-8.2 × 10 −8: Adenosine triphosphate: Energy storage total 3.1-5.7 × 10 −4 ...
Fibrinogen is made and secreted into the blood primarily by liver hepatocyte cells. Endothelium cells are also reported to make small amounts of fibrinogen, but this fibrinogen has not been fully characterized; blood platelets and their precursors, bone marrow megakaryocytes, while once thought to make fibrinogen, are now known to take up and store but not make the glycoprotein.
Serum sample preparation requires about 30 minutes of waiting time before it can be centrifuged and then analyzed. [23] However, coagulation can be hastened down to a few minutes by adding thrombin or similar agents to the serum sample. [25] Compared to serum, 15–20% larger volume of plasma can be obtained from a blood sample of certain size.
Blood serum and blood plasma are similar, but serum does not contain any clotting factors such as fibrinogen, prothrombin, thromboplastin and many others. Serum includes all proteins not used in coagulation (clotting) and all the electrolytes, antibodies, antigens, hormones and any exogenous substances, such as drugs and microorganisms.
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Plasma contains a large variety of proteins including albumin, immunoglobulins, and clotting proteins such as fibrinogen. [1] Albumin constitutes about 60% of the total protein in plasma and is present at concentrations between 35 and 55 mg/mL. [2]