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  2. Acute lymphoblastic leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

    Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. [1] Symptoms may include feeling tired, pale skin color, fever , easy bleeding or bruising, enlarged lymph nodes , or bone pain. [ 1 ]

  3. Blinatumomab - Wikipedia

    en.wikipedia.org/wiki/Blinatumomab

    In July 2014, the FDA granted breakthrough therapy status to blinatumomab for the treatment of acute lymphoblastic leukemia (ALL). [12] In October 2014, Amgen's Biologics License Application for blinatumomab was granted priority review designation by the FDA, thus establishing a deadline of 19 May 2015, for completion of the FDA review process ...

  4. T-cell acute lymphoblastic leukemia - Wikipedia

    en.wikipedia.org/wiki/T-cell_acute_lymphoblastic...

    Currently, standard treatment for T-cell acute lymphoblastic leukemia (T-ALL) involves long-term chemotherapy and medication to prevent or treat side effects associated with low white blood cell counts resulting from intensive chemotherapy regimens. The treatment typically occurs in three stages: induction, consolidation, and maintenance. [3]

  5. Obecabtagene autoleucel - Wikipedia

    en.wikipedia.org/wiki/Obecabtagene_autoleucel

    Obecabtagene autoleucel, sold under the brand name Aucatzyl, is an anti-cancer medication used for the treatment of acute lymphoblastic leukemia. [1] [2] It is a CD19-directed genetically modified autologous T-cell immunotherapy.

  6. Leukemia - Wikipedia

    en.wikipedia.org/wiki/Leukemia

    Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and acute biphenotypic leukemia. While most cases of ALL occur in children, 80% of deaths from ALL occur in adults. [17] Chronic lymphocytic leukemia (CLL) most often affects adults over the age of 55. It sometimes occurs in ...

  7. Tisagenlecleucel - Wikipedia

    en.wikipedia.org/wiki/Tisagenlecleucel

    Tisagenlecleucel is indicated for the treatment of those under 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse; or adults with relapsed or refractory (r/r) large B-cell lymphoma after two or more lines of systemic therapy including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, high grade B-cell lymphoma ...

  8. Asparaginase - Wikipedia

    en.wikipedia.org/wiki/Asparaginase

    Numerous clinical studies have been conducted to evaluate the efficacy and safety of Erwinase in the treatment of acute lymphoblastic leukemia. One of the primary concerns in acute lymphoblastic leukemia treatment is the occurrence of adverse events (AEs) associated with asparaginase therapy.

  9. FLAG (chemotherapy) - Wikipedia

    en.wikipedia.org/wiki/FLAG_(chemotherapy)

    FLAG and FLAG-based regimens can also be used in cases of concomitant AML and either acute lymphoblastic leukemia (ALL) or lymphoma. Because fludarabine is highly active in lymphoid malignancies, these regimens can further be used when patients have biphenotypic AML, in which cells display properties of both myeloid and lymphoid cells.

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