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An example demonstrating how drug combination with additive effect can cause adverse effects is the co-administration of ACEI and potassium-sparing diuretics. [3] Despite having different mechanisms of action, the drugs are able to reduce potassium excretion from the body.
A classic example of this effect is the interaction between β-lactams, which damage the bacteria cell membrane, and aminoglycosides, which inhibit protein synthesis. [1] The damage dealt to the cell wall by β-lactams allows more aminoglycoside molecules to be taken up into the cell than would otherwise be possible, enhancing cell damage. [ 1 ]
A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs. Interactions may occur by simultaneous targeting of receptors , directly or indirectly. For example, both Zolpidem and alcohol affect GABA A receptors , and their simultaneous consumption results in the overstimulation of the receptor, which can ...
The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [12] The sort and extent of altered cellular physiology will depend on the combination of the drug's presence (as established by pharmacokinetic (PK) studies) and/or its mechanism and duration of ...
UK Health and Safety Executive, Successful health and safety management (1997): this book describes the principles and management practices, which provide the basis of effective health and safety management. It sets out the issues that need to be addressed, and can be used for developing improvement programs, self-audit, or self-assessment.
Drug Research is abstracted and indexed in: . Biological Abstracts; Chemical Abstracts; Excerpta Medica; Index Medicus; Nuclear Science Abstracts; According to the Journal Citation Reports, it has a 2014 impact factor of 0.701, ranking it 121st out of 157 journals in the category "Chemistry, multidisciplinary" [1] and 229th out of 254 journals in the category "Pharmacology & Pharmacy".
As of 2023, Annual Review of Pharmacology and Toxicology is being published as open access, under the Subscribe to Open model. [1] As of 2024, Journal Citation Reports lists the journal's 2023 impact factor as 11.2, ranking it second of 106 journal titles in the category "Toxicology" and ninth of 354 titles in the category "Pharmacology ...
There is a need to identify all of the ways, directly and indirectly, that diseases can interact and have, as a result, enhanced impact on human health. Third there is a need for the development of an eco-syndemic understanding of the ways in which global warming contributes to the spread of diseases and new disease interactions. There is a ...