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Relaxin is a protein hormone of about 6000 Da, [1] first described in 1926 by Frederick Hisaw. [2] [3]The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
All seven relaxin family peptide hormones are synthesized as pre-prohormones, and subsequently cleaved to form two chains stabilized by an intra-α-chain and two disulfide bonds. [5] Members of the human relaxin peptide family share a similar tertiary structure, composed of a β-chain, c-chain, and α-chain at their carboxyl-terminal.
Relaxin-3 is a neuropeptide that was discovered in 2001, [1] and which is highly conserved in species ranging from flies, fish, rodents and humans. [2] Relaxin-3 is a member and ancestral gene of the relaxin family of peptides, which includes the namesake hormone relaxin (designated 'H2 relaxin' in humans) which mediates peripheral actions ...
There are three relaxin genes in humans. [2] One type, H2, is made and secreted in the ovaries, as well as in the mammary glands. [2] Relaxin acts via locally expressed specific receptors located on parenchyma and myoepithelial cells. [2] It reaches peak concentrations 24-48 hours after birth and then declines. [2]
In psychology, relaxation is the emotional state of low tension, in which there is an absence of arousal, particularly from negative sources such as anger, anxiety, or fear. [2] Relaxation is a form of mild ecstasy coming from the frontal lobe of the brain in which the backward cortex sends signals to the frontal cortex via a mild sedative.
However, it's important to note that these benefits may vary based on the type of wine consumed, specifically red and white wine,” says Lauren Manaker, M.S., RDN, LD, CLEC, Charleston-based ...
The following is a list of hormones found in Homo sapiens.Spelling is not uniform for many hormones. For example, current North American and international usage uses [citation needed] estrogen and gonadotropin, while British usage retains the Greek digraph in oestrogen and favours the earlier spelling gonadotrophin.
For policymakers, denying addicts the best scientifically proven treatment carries no political cost. But there’s a human cost to maintaining a status quo in which perpetual relapse is considered a natural part of a heroin addict’s journey to recovery. Relapse for a heroin addict is no mere setback. It can be deadly.