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Fungal keratitis is a fungal infection of the cornea, which can lead to blindness. [2] It generally presents with a red, painful eye and blurred vision. [1] There is also increased sensitivity to light, and excessive tears or discharge. [1] It is caused by fungal organisms such as Fusarium, Aspergillus or Candida.
Corneal ulcer, also called keratitis, is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. [ 1 ] [ 2 ] [ 3 ] It is a common condition in humans particularly in the tropics and in farming. [ 4 ]
Keratitis is a condition in which the eye's cornea, the clear dome on the front surface of the eye, becomes inflamed. [1] The condition is often marked by moderate to intense pain and usually involves any of the following symptoms: pain, impaired eyesight, photophobia (light sensitivity), red eye and a 'gritty' sensation. [2]
Once diagnosis is accessed, "specific anti-fungal therapy" [2] can be administered. [2] One of the most popular and common treatments used "for life-threatening and severe ophthalmic mycoses" [2] is amphotericin B which is a specific anti-fungal drug. [2] For the treatment for filamentous fungal keratitis, "topical natamycin is usually the ...
Treatment is generally performed using antifungal medicines, usually in the form of a cream or by mouth or injection, depending on the specific infection and its extent. [15] Some require surgically cutting out infected tissue. [3] Fungal infections have a world-wide distribution and are common, affecting more than one billion people every year ...
Both treatments have the same target: an enzyme called dihydroorotate dehydrogenase. According to Van Rhijn, there are other antifungal drugs in the pipeline that are following the same trajectory ...
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