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Whereas the IC 50 value for a compound may vary between experiments depending on experimental conditions, (e.g. substrate and enzyme concentrations) the K i is an absolute value. K i is the inhibition constant for a drug; the concentration of competing ligand in a competition assay which would occupy 50% of the receptors if no ligand were present.
The PDBbind database is a comprehensive collection of experimentally measured binding affinity data (Kd, Ki, and IC50) for the protein-ligand complexes deposited in the Protein Data Bank (PDB). [ 1 ] [ 2 ] It thus provides a link between energetic and structural information of protein-ligand complexes, which is of great value to various studies ...
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. [1]Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.
Some calculators run a subset of Fortran 77 called Mini-Fortran; the compiler is on the calculator so connecting to a PC to put programs onto the machine is not needed. The OnCalc C Compiler for the Casio fx-9860 series is now available. The Sharp PC G850V pocket computer has an onboard C compiler in addition to an assembler and a Basic ...
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Inhibitors have IC50 values so I tried to reintegrate it with information already present in the article. I think that including it in the lead paragraph would mislead people into thinking it was a discussion about inhibitors not The IC50 concept Lilypink 19:04, 5 November 2007 (UTC) IC50 is not a pharmacological constant! pA2 is a constant.
The phrase "IBM PC compatible self-booting disk" is sometimes shortened to "PC booter". Self-booting disks were common for other computers as well. These games were distributed on 5 + 1 ⁄ 4 " or, later, 3 + 1 ⁄ 2 ", floppy disks that booted directly, meaning once they were inserted in the drive and the computer was turned on, a minimal ...
A simple arithmetic calculator was first included with Windows 1.0. [5]In Windows 3.0, a scientific mode was added, which included exponents and roots, logarithms, factorial-based functions, trigonometry (supports radian, degree and gradians angles), base conversions (2, 8, 10, 16), logic operations, statistical functions such as single variable statistics and linear regression.