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Diphenhydramine, available in various salt forms, [76] such as citrate, [77] [78] hydrochloride, [79] and salicylate, [80] exhibits distinct molecular weights and pharmacokinetic properties. Specifically, diphenhydramine hydrochloride and diphenhydramine citrate possess molecular weights of 291.8 g/mol [ 81 ] and 447.5 g/mol , [ 82 ] respectively.
Diphenhydramine hydrochloride is also marketed as an antihistamine in Canada under the same name, and is only listed in the Canadian Agricultural database for equine use. [5] However, a 2019 manual for counseling professionals in Canada included Sominex as a medicine to be used for the treatment of Parkinson's tremors and stiffness related to ...
ZzzQuil is a sleep aid, and is not a treatment for pain or cold/flu symptoms. Its active ingredient is: Diphenhydramine HCl 50 mg (antihistamine) Children's NyQuil
Benadryl Allergy is widely used as a sleep aid among adults. While it is not marketed as an over-the-counter (OTC) sleeping aid, most versions of Benadryl contain diphenhydramine, a drug with sedative properties. [6] Diphenhydramine (Benadryl) has also been used by parents to help improve their infant's sleep habits.
Naproxen/diphenhydramine (trade name Aleve PM) is a formulation of naproxen with diphenhydramine marketed by Bayer Healthcare. [1] It is made as an over-the-counter drug . The intended use of the drug is relieve pain specifically when going to sleep.
The shorter elimination half-life of diphenhydramine (4–8 hours) compared to doxylamine may give it an advantage over doxylamine as a sleep aid in this regard. [27] Antihistamines like doxylamine are sedating initially but tolerance occurs with repeated use and can result in rebound insomnia upon discontinuation. [7] [28]
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