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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
They are indicated to treat diseases related to the heart or the vascular system (blood vessels), such as hypertension, hyperlipidemia, coagulation disorders, heart failure and coronary artery disease. [1] These drugs are prescription-only medicines, meaning that they should be administered strictly under a doctor’s instruction and can only ...
The most important adverse side effects are muscle problems, an increased risk of diabetes mellitus, and increased liver enzymes in the blood due to liver damage. [ 5 ] [ 65 ] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke , and 5 cases of muscle damage per 10,000 people treated. [ 34 ]
Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic agents are a diverse group of pharmaceuticals that are used to lower the level of lipids and lipoproteins, such as cholesterol, in the blood (hyperlipidemia). The American Heart Association recommends the descriptor ...
Semaglutide drug use were linked to better kidney health in people with obesity and established heart disease in a new study. Image credit: Iuliia Burmistrova/Getty Images.
Enterohepatic circulation of drugs. Enterohepatic circulation is the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.
Eli Lilly's tirzepatide, the active ingredient in its popular diabetes drug Mounjaro, helped up to 74% of patients achieve absence of a severe type of fatty liver disease with no worsening of ...
Compromised liver or kidney function with drugs that inhibit an enzyme called CYP3A4 [46] Pre-existing ophthalmopathy (eye disorders) [ 47 ] Avoid usage during pregnancy as it can inhibit meiosis , a specific form of cell division that takes place in oocytes , which are specialized reproductive cells in females [ 48 ]
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