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4-Chloroaniline is used in the industrial production of pesticides, drugs, and dyestuffs. It is a precursor to the widely used antimicrobial and bacteriocide chlorhexidine and is used in the manufacture of pesticides, including pyraclostrobin , anilofos , monolinuron , and chlorphthalim .
4-Chloro-o-toluidine (4-COT, 4-chloro-2-methylaniline) is the organic compound with the formula CH 3 C 6 H 3 Cl(NH 2). It is a colorless solid. The compound is produced as an intermediate to the pesticide chlordimeform and a precursor to some azo dyes. Production has declined after it was shown to be highly carcinogenic.
In 1972–1973, Philippines was beset by rice production shortfalls resulting from the series of typhoons and floods and fertilizer shortages spawned by the oil crisis.The resulting fourfold drop in rice production prompted the government to directly intervene in the operations of the fertilizer industry through the issuance of Presidential Decree (P.D.)
4,4′-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production. [3] MOCA is an aromatic amine which is structurally similar to benzidine , a known human bladder carcinogen.
Some organochlorides are considered safe enough for consumption in foods and medicines. For example, peas and broad beans contain the natural chlorinated plant hormone 4-chloroindole-3-acetic acid (4-Cl-IAA); [16] [17] and the sweetener sucralose (Splenda) is widely used in diet products.
Although toxic, and recommended to be avoided by humans, pyraclostrobin is of temporary and low toxicity, that is to say it is merely an irritant [12] of eyes and skin. [8] ...
The number of incidents per 1,000 applications for all illnesses ranged from 0.11 to 0.21. The US National Pesticides Telecommunications Network database collected reports from 1984 to 1991 showing 91 human, 9 animal and 31 other poisoning incidents for a total of 131 incidents involving dicofol from 571 phone calls made to the hotline.
4,7-Dichloroquinoline was first reported in a patent filed by IG Farben in 1937. [2] However, its synthesis was not investigated in detail until chloroquine was developed as an antimalarial drug. [ 3 ] : 130–132 A route to the intermediate starting from 3-chloroaniline was developed by chemists at Winthrop Chemical Co .