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The simplest types of control are negative and positive controls, and both are found in many different types of experiments. [2] These two controls, when both are successful, are usually sufficient to eliminate most potential confounding variables: it means that the experiment produces a negative result when a negative result is expected, and a ...
Positive feedback loops play a role by switching cells from low to high Cdk-activity. The interaction between the two types of loops is evident in mitosis. While positive feedback initiates mitosis, a negative feedback loop promotes the inactivation of the cyclin-dependent kinases by the anaphase-promoting complex.
In prokaryotes, a well-known activator protein is the catabolite activator protein (CAP), involved in positive control of the lac operon. In the regulation of gene expression, studied in evolutionary developmental biology (evo-devo), both activators and repressors play important roles. [4]
inhibition of run-away reactions when coupled with a positive feedback loop; creating an oscillator by taking advantage in the time delay of transcription and translation, given that the mRNA and protein half-life is shorter; positive feedback: the gene product upregulates its own production directly or indirectly, which can result in
In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is ...
Positive feedback in chemical reactions can increase the rate of reactions, and in some cases can lead to explosions. Positive feedback in mechanical design causes tipping-point, or over-centre, mechanisms to snap into position, for example in switches and locking pliers. Out of control, it can cause bridges to collapse.
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
Control coefficients can have both negative and positive values. A negative value indicates that the observable in question decreases as a result of the change in enzyme activity. It is important to note that control coefficients are not fixed values but will change depending on the state of the pathway or organism. If an organism shifts to a ...