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Chlorhexidine [1] is a disinfectant and antiseptic with the molecular formula C 22 H 30 Cl 2 N 10, which is used for skin disinfection before surgery and to disinfect surgical instruments. [2] It is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking. [3]
Dakin's solution is a dilute solution of sodium hypochlorite (0.4% to 0.5%) and other stabilizing ingredients, traditionally used as an antiseptic, e.g. to cleanse wounds in order to prevent infection. [1] The preparation was for a time called also Carrel–Dakin solution or Carrel–Dakin fluid. [2]
In a 2016 in vitro study of mouth rinses on gingival fibroblasts and epithelial cells octenidine showed a less cytotoxic effect, especially on epithelial cells, compared to chlorhexidine after 15 min. [9] Wound irrigation with octenidine has caused severe complications in dogs, [10] aseptic necrosis and chronic inflammation in penetrating hand ...
It is used as a 1-3 % solution for cleaning roadside accident wounds. [3] ICI also introduced Savlon, which was a combination of cetrimide and chlorhexidine. ICI later sold the Savlon brand OTC to Johnson & Johnson in May 1992. [4]
Surgilube is a surgical lubricant made of natural water-soluble gums that also contains the antiseptic chlorhexidine gluconate. [1] K-Y Jelly was initially used as a surgical lubricant before it gained popularity as a personal lubricant. [citation needed]
As antiseptics (i.e., germicide agents that can be used on human or animal body, skin, mucosae, wounds and the like), few of the above-mentioned disinfectants can be used, under proper conditions (mainly concentration, pH, temperature and toxicity toward humans and animals). Among them, some important are
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