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Men without prostate cancer typically have PSA levels of under 4 nanograms per milliliter (ng/mL), according to the American Cancer Society. PSA levels between 4 and 10 suggest you could have ...
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. [16] A 2018 United States Preventive Services Task Force (USPSTF) recommendation adjusted the prior opposition to PSA screening, [17] suggesting shared decision-making regarding screening in healthy males 55 to 69 years of age. [17]
Men with high PSA levels are often recommended to repeat the blood test four to six weeks later, as PSA levels can fluctuate unrelated to prostate cancer. [17] Benign prostatic hyperplasia, prostate infection, recent ejaculation, and some urological procedures can increase PSA levels; taking 5α-reductase inhibitors can decrease PSA levels. [15]
THE PSA IS a good initial “check engine light” for the prostate, says Garrett Pohlman, M.D., a urologist and host of The Prostate Health Podcast. But it can just tell you that PSA levels are ...
The Scandinavian Prostate Cancer Group Study-4 (SPGS-4) randomized 695 men (mean age 65 years) to observation versus radical prostatectomy; 5% were diagnosed through PSA based screening, 3 of 4 had palpable disease, and the mean PSA level was 13 ng/ml at diagnosis. [9]
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