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Currently, over 100 countries have regulations regarding mycotoxins in the feed industry, in which 13 mycotoxins or groups of mycotoxins are of concern. [54] The process of assessing a regulated mycotoxin involves a wide array of in-laboratory testing that includes extracting, clean-up columns, [ 55 ] and separation techniques. [ 56 ]
Mycotoxins are not produced all the time, but only under specific growing conditions. Mycotoxins are harmful or lethal to humans and animals only when exposure is high enough. [46] [47] Mycotoxins can be found on the mold spore and mold fragments, and therefore they can also be found on the substrate upon which the mold grows.
T-2 mycotoxin is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and other animals. The clinical condition it causes is alimentary toxic aleukia and a host of symptoms related to organs as diverse as the skin, airway, and stomach.
Aflatoxin B 1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Aflatoxin M 1 is present in the fermentation broth of Aspergillus parasiticus, but it and aflatoxin M 2 are also produced when an infected liver metabolizes aflatoxin B 1 and B 2.
The trichothecene mycotoxins are toxic to humans, other mammals, birds, fish, a variety of invertebrates, plants, and eukaryotic cells. [21] The specific toxicity varies depending on the particular toxin and animal species, however the route of administration plays a significantly higher role in determining lethality.
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Mycotoxicology is the branch of mycology that focuses on analyzing and studying the toxins produced by fungi, known as mycotoxins. [1] In the food industry it is important to adopt measures that keep mycotoxin levels as low as practicable, especially those that are heat-stable.