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Remyelination is the process of propagating oligodendrocyte precursor cells to form oligodendrocytes to create new myelin sheaths on demyelinated axons in the Central nervous system (CNS). This is a process naturally regulated in the body and tends to be very efficient in a healthy CNS. [ 1 ]
In stem cell research, Dr. Fehlings' 2006 paper in the Journal of Neuroscience (Karimi-Abdolrezaee et al., 2006; [7]) provides strong evidence of the functional impact of neural stem cells in repairing/regenerating injured spinal cords through remyelination of axons. This finding has been key in leading clinical translational efforts to use ...
In chronic MS lesions where remyelination is incomplete, there is evidence that there are oligodendrocytes with processes extending toward demyelinated axons, but they do not seem to be able to generate new myelin. [63] The mechanisms that regulate differentiation of OPCs into myelinating oligodendrocytes are an active area of research.
“By carefully studying the biology of remyelination, we’ve developed a precise therapy to activate it — the first of a new class of MS therapies,” he added. Animal and phase 1 human trials ...
Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.Therefore, the first stage of myelinogenesis is often defined as the differentiation of oligodendrocyte progenitor cells (OPCs) or Schwann cell progenitors into their mature counterparts, [4] followed by myelin formation around axons.
The researchers used RNA sequencing and brain-mapping tools to analyze more than 1.2 million brain cells from young mice (2 months old) and older mice (18 months old).
A repair process, called remyelination, takes place in early phases of the disease, but the oligodendrocytes are unable to completely rebuild the cell's myelin sheath. Repeated attacks lead to successively less effective remyelinations, until a scar-like plaque is built up around the damaged axons.
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