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The life expectancy increased markedly in those who tested negative for bone marrow MRD before their allogeneic transplant. The MRD-negative patients had a leukemia-free survival rate of 83% and overall survival rate of 92% – much higher when compared with patients with persistent MRD.
You might need a bone marrow transplant if your bone marrow stops working and does not produce enough healthy blood cells. Bone marrow transplants may use cells from your own body (autologous transplant) or from a donor (allogeneic transplant).
The overall risk of death after transplant dropped 34% between 2003-2007 and 2013-2017, according to new research published in Annals of Internal Medicine. Those gains stem from a sharp decline in transplant-related complications, said corresponding author Dr. George McDonald, an emeritus member at Fred Hutch.
Data on patient demographics (age at BMT, sex, and race/ethnicity), primary diagnosis, stem-cell source (bone marrow or PBSC), exposure to TBI for conditioning, and disease status at transplantation (high or standard risk for recurrence) were obtained from institutional transplant databases.
Healthcare providers may use stem cell transplants (bone marrow transplants) to treat blood disorders and certain kinds of cancer or autoimmune diseases. The transplants replace unhealthy stem cells with healthy stem cells.
A 2016 study of over 6,000 adults with AML found that people who received an autologous bone marrow transplant had a 5-year survival rate of 65%.
As with any procedure, in bone marrow transplant the prognosis and long-term survival can vary greatly from person to person. The number of transplants being done for an increasing number of diseases, as well as ongoing medical developments, have greatly improved the outcome for bone marrow transplant in children and adults.
Life expectancy, survival rates, and quality of life after a bone marrow transplant have vastly improved due to: improvements in accurate donor matching antibiotic treatment to control...
Mayo Clinic doctors' experience and integrated team approach result in transplant outcomes that compare favorably with national averages. Teams work with transplant recipients before, during and after your transplant to ensure the greatest likelihood of superior results.
A, Overall survival by transplant era for patients younger than 18 years at blood or marrow transplantation (BMT). B, Overall survival by transplant era for patients who received bone marrow. Shaded areas indicate 95% CIs.