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  2. Dopamine receptor D1 - Wikipedia

    en.wikipedia.org/wiki/Dopamine_receptor_D1

    D 1 receptor has a high degree of structural homology to another dopamine receptor, D 5, and they both bind similar drugs. [13] As a result, none of the known orthosteric ligands is selective for the D 1 vs. the D 5 receptor, but the benzazepines generally are more selective for the D 1 and D 5 receptors versus the D 2-like family. [12]

  3. Ecopipam - Wikipedia

    en.wikipedia.org/wiki/Ecopipam

    Human clinical studies also showed that ecopipam was an effective antagonist of the acute euphoric effects of cocaine. [9] However, the effect did not persist following repeated administration. [10] Researchers have postulated that dopamine via D 1 receptors in the mesolimbic system is involved with rewarded behaviors and pleasure. [11]

  4. Dopamine agonist - Wikipedia

    en.wikipedia.org/wiki/Dopamine_agonist

    There are two fundamental ways of treating Parkinson's disease, either by replacing dopamine or mimicking its effect. [1] Dopamine agonists act directly on the dopamine receptors and mimic dopamine's effect. [1] Dopamine agonists have two subclasses: ergoline and non-ergoline agonists. Both subclasses target dopamine D 2-type receptors.

  5. Dopamine receptor - Wikipedia

    en.wikipedia.org/wiki/Dopamine_receptor

    Dopamine receptors can also transactivate Receptor tyrosine kinases. [19] Beta Arrestin recruitment is mediated by G-protein kinases that phosphorylate and inactivate dopamine receptors after stimulation. While beta arrestin plays a role in receptor desensitization, it may also be critical in mediating downstream effects of dopamine receptors.

  6. Dopamine antagonist - Wikipedia

    en.wikipedia.org/wiki/Dopamine_antagonist

    Dopamine receptor flow chart. Dopamine receptors are all G protein–coupled receptors, and are divided into two classes based on which G-protein they are coupled to. [1] The D 1-like class of dopamine receptors is coupled to Gα s/olf and stimulates adenylate cyclase production, whereas the D 2-like class is coupled to Gα i/o and thus inhibits adenylate cyclase production.

  7. D1-like receptor - Wikipedia

    en.wikipedia.org/wiki/D1-like_receptor

    The D 1-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. [1] The D 1 -like subfamily consists of two G protein–coupled receptors that are coupled to G s and mediate excitatory neurotransmission , of which include D 1 and D 5 . [ 2 ]

  8. Dopamine therapy - Wikipedia

    en.wikipedia.org/wiki/Dopamine_therapy

    Dopamine therapy is the regulation of levels of the neurotransmitter dopamine through the use of either agonists, or antagonists; and has been used in the treatment of disorders characterized by a dopamine imbalance. Dopamine replacement therapy (DRT) is an effective treatment for patients with decreased levels of dopamine.

  9. Fenoldopam - Wikipedia

    en.wikipedia.org/wiki/Fenoldopam

    The renal effect of fenoldopam and dopamine may involve physiological antagonism of the renin-angiotensin system in the kidney. [7] In contrast to dopamine, fenoldopam is a selective D 1 receptor agonist with no effect on beta adrenoceptors, although there is evidence that it may have some alpha-1 [8] and alpha-2 adrenoceptor antagonist ...