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5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.
AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming ...
The AMPK pathway is related to LKB1 and altered in non-small-cell lung cancer. [9] [12] A non-small-cell lung cancer altered AMPK pathway can be reinitiated by treatment with the type 2 diabetes medication Metformin. [9] [13] [14] Shaw uses a combination of genetic engineering in mice and interdisciplinary studies across cancer, diabetes ...
AMPK may refer to: AMP-activated protein kinase, an enzyme (acetyl-CoA carboxylase) kinase, an enzyme This page was last edited on 15 May 2022, at ...
The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumour suppressor.. LKB1 is a primary upstream kinase of adenosine monophosphate-activated protein kinase (), a necessary element in cell metabolism that is required for maintaining energy homeostasis.
In 1950 the next generation of tactical trucks were being developed. Sizes were rationalized, with 1 ⁄ 4 and 3 ⁄ 4-ton 4x4s and 2 + 1 ⁄ 2, 5, and 10-ton 6x6s. Trucks were military standard designs, 6x6 trucks used common cabs and similar fender and hood styles. [14]
A truck with a bucket-like cargo area which the front can be raised, hinging on the rear, allowing the load to slide ("dump") out of the cargo area. Often a straight truck, semi-trailers are also common. Flatbeds and refuse container trucks can often "dump", but are rarely called that. [3] Eighteen-wheeler
A daytime running lamp (DRL, also daytime running light) is an automotive lighting and bicycle lighting device on the front of a road going motor vehicle or bicycle. [1] It is automatically switched on when the vehicle's handbrake has been pulled down, when the vehicle is in gear , or when the engine is started, emitting white, yellow , or ...
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