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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
One reason depression is thought to be a pathology is that it causes so much psychic pain and distress. However, physical pain is also very distressful, yet it has an evolved function: to inform the organism that it is being damaged, to motivate it to withdraw from the source of damage, and to learn to avoid such damage-causing circumstances in the future.
Endogenous depression is an atypical subclass of major depressive disorder (clinical depression). It could be caused by genetic and biological factors. [ 1 ] Endogenous depression occurs due to the presence of an internal (cognitive, biological) stressor instead of an external (social, environmental) stressor. [ 2 ]
The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.
This suggests that antidepressants need to affect other biological systems, apart from monoamines, in order to reduce depressive symptoms. Relationship between neurogenesis and depression. Stress has been reported to impair many aspects of hippocampal neurogenesis, including: [3] Proliferation rate of neural progenitor cells
Depression affects around 14.8 million adults in the U.S. That?s around 7 percent of the entire population aged 18 and over.
Unlike biological and psychological causes, environmental causes denote a wide range of stressors that individuals experience in everyday life. They are more psychologically than biologically based. [72] Events that evoke feelings of loss are the most likely to cause a mental disorder to develop in an individual. [13]
Shift work can kill you 15 years sooner, warns Whoop’s chief scientist, while dramatically raising your risk for depression and suicide Eleanor Pringle January 4, 2024 at 11:49 AM
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