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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [3] [4] [2] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can cause ...
Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene. [ 5 ] [ 6 ] [ 7 ] Function
In evolutionary developmental biology, homeosis is the transformation of one organ into another, arising from mutation in or misexpression of certain developmentally critical genes, specifically homeotic genes. In animals, these developmental genes specifically control the development of organs on their anteroposterior axis. [1]
Ladybird homeobox 2 (LBX2) is a protein that is encoded by the LBX2 gene, located on the second chromosome [5] in humans, and on the sixth chromosome in mice. [ 6 ] LBX2 belongs to the homeobox gene family, which plays important roles in embryonic development and tissue differentiation.
Gene clusters often result from expansions of a single gene caused by repeated duplication events, and may be observed near one another on the same chromosome or on different, but homologous chromosomes. An example of a gene cluster is the Hox gene, which is made up of eight genes and is part of the Homeobox gene family.
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body. For example, Hox genes in insects specify ...
4211 17268 Ensembl ENSG00000143995 ENSMUSG00000020160 UniProt O00470 Q60954 RefSeq (mRNA) NM_002398 NM_001193271 NM_010789 RefSeq (protein) NP_002389 NP_001180200 NP_034919 Location (UCSC) Chr 2: 66.43 – 66.57 Mb Chr 11: 18.83 – 18.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene. Function Homeobox ...
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene. [ 5 ] [ 6 ] This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.