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Lufenuron is the active ingredient in the veterinary flea control medication Program, and one of the two active ingredients in the flea, heartworm, and anthelmintic medicine milbemycin oxime/lufenuron (Sentinel). Lufenuron is stored in the animal's body fat and transferred to adult fleas through the host's blood when they feed.
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit , on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation .
Animal testing. Institutional Animal Care and Use Committees (IACUCs) are centrally important in applying laws about animal research in the United States. Similar systems operate in other countries, but generally under different titles; for example, in Canada a typical title would be the University Animal Care Committee (UACC) [1], while in the ...
The FDA animal efficacy rule (also known as animal rule) applies to development and testing of drugs and biologicals to reduce or prevent serious or life-threatening conditions caused by exposure to lethal or permanently disabling toxic agents (chemical, biological, radiological, or nuclear substances), where human efficacy trials are not feasible or ethical. [1]
The Institute for Laboratory Animal Research (ILAR) is a United States organization which develops and shares information and guidelines about animal testing and care of laboratory animals. [1] It is a unit in the United States National Research Council. Their mission is "to evaluate and to report on scientific, technological, and ethical use ...
“I wouldn’t have found my cancer for another year — at my next scheduled mammogram — except that my OBGYN, Dr. Thaïs Aliabadi, decided to calculate my Breast Cancer Risk Assessment Score ...
Animal testing, science, medicine, animal welfare, animal rights, ethics. Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals, such as model organisms, in experiments that seek to control the variables that affect the behavior or biological system under study.
“Ask your doctor to calculate your Breast Cancer Assessment Score,” Munn said. “Dr. Aliabadi says that if the number is greater than 20%, you need annual mammograms and breast MRIs starting ...