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Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms.
Nicotine is highly addictive and is a leading cause of premature death worldwide. Great diversity in neuronal nicotinic acetylcholine receptors arises from their subunit composition. Genetic factors, especially within the CHRNA5-A3-B4 gene cluster, play an important role in nicotine addiction.
The nicotinic acetylcholine receptor (nAChR) is a typical ion channel type receptor. nAChR agonists such as nicotine evoke rapid excitatory responses in order of milliseconds.
Nicotinic Acetylcholine Receptors. The nicotinic acetylcholine (nACh) receptors are fast ionotropic receptors that are composed of distinct subunits, α, β, δ, ϵ, and γ, and are arranged in different pentameric combinations around a ligand-gated excitatory ion channel permeable to Na +, K +, and Ca 2+ ions.
The nicotinic acetylcholine (ACh) receptor, at the neuromuscular junction, is a neurotransmitter-gated ion channel that has been fine-tuned through evolution to transduce a chemical signal into an electrical signal with maximum efficiency and speed. ...
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be divided into two groups: muscle receptors, which are found at the skeletal neuromuscular junction where they mediate neuromuscular transmission, and neuronal receptors, which are found throughout the peripheral and c ….
Binding by endogenous (acetylcholine) or exogenous (nicotine) agonists to nAChR opens an intrinsic ion channel in the receptor, allowing the flow of cation ions (Na +, Ca 2+, and K +) through the...
Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins from a...
Basic structure of nicotinic acetylcholine receptors (nAChRs). A: the basic linear sequence of all nAChR subunits appears as a large extracellular domain, four transmembrane domains, and a cytoplasmic domain of variable size that resides between TM3 and TM4.
The nicotinic acetylcholine receptor is the best characterized neurotransmitter receptor. The nicotinic receptor was purified about a decade before purification of other neurotransmitter receptors.