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A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. [ 1 ]
Epithelioid cell granuloma can be defined as specifically and structurally organized collection of epithelioid cells, macrophages, lymphocytes and dendritic cells. Foreign-body granulomas may be considered an organized collection of macrophages, including mere collections of giant cells surrounding inert substances like suture material – the ...
The disease is still sometimes confused with lethal midline granuloma and lymphomatoid granulomatosis, both malignant lymphomas. [ 34 ] The full clinical picture was first presented by Friedrich Wegener (1907–1990), a German pathologist , in two reports in 1936 and 1939, leading to the eponymous name Wegener's granulomatosis or Wegener ...
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, [1] is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. [2]
Annular elastolytic giant-cell granuloma (also known as "Giant cell elastophagocytosis," [1] "Meischer's granuloma," [2] "Miescher's granuloma of the face" [1]) is a cutaneous condition characterized histologically by a dermal infiltrate of macrophages.
Granulation tissue with a poorly formed granuloma to the left of centre. Within this area there is a multinucleate giant cell of the Langhans type. The patient had a healing mycobacterial infection of the skin (Mycobacterium ulcerans infection). Langhans giant cells (LGC) are giant cells found in granulomatous conditions.
Through the release of Interleukin 4 (IL-4) and Interleukin 13 (IL-13) by TH2, or T helper cells, and mast cells, these macrophages can fuse to form foreign body giant cells. [1] [4] The macrophages are initially attracted to the injury/infection site through a variety of chemoattractants like growth factors, platelet factors, and interleukins. [4]
The main immune cells active in the tissue are macrophages and neutrophils, although other leukocytes are also present. [6] These work to phagocytize old or damaged tissue, and protect the healing tissue from pathogenic infection. This is necessary both to aid the healing process and to protect against invading pathogens, as the wound often ...