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Pepto-Bismol is an over-the-counter drug currently produced by the Procter & Gamble company in the United States, Canada and the United Kingdom. Pepto-Bismol is made in chewable tablets [ 24 ] and swallowable caplets, [ 25 ] but it is best known for its original formula, which is a thick liquid.
The active ingredients have varied over time, and are different between the United States and Canada. The original active ingredients were kaolinite and pectin. In Canada and Switzerland, the active ingredient is now Attapulgite, [1] while in the US, the active ingredient is now bismuth subsalicylate (the same as in Pepto-Bismol).
Pepto-Bismol over-the-counter drug for minor digestive system upset (acquired as part of Norwich Eaton Pharmaceuticals in 1982) Prilosec OTC (licensed from AstraZeneca) Rolaids (acquired in 2024 from Lil' Drug Store Products) Sangobion (acquired from Merck Group) Scope mouthwash; Seven Seas (acquired from Merck Group) Vicks cough and cold products
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The company’s mixture called Cholera Infantum, later renamed Pepto-Bismol, appeared for the first time in 1901. Its principal use was for infants with severe diarrhea. In 1907, Acetylsalicylic acid tablets were added to the company’s product line.
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Bismuth subsalicylate is used to treat diarrhea; [9] it is the active ingredient in such "pink bismuth" preparations as Pepto-Bismol, as well as the 2004 reformulation of Kaopectate. It is also used to treat some other gastro-intestinal diseases like shigellosis [ 72 ] and cadmium poisoning . [ 9 ]