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Myosin V is an unconventional myosin motor, which is processive as a dimer and has a step size of 36 nm. [34] It translocates (walks) along actin filaments traveling towards the barbed end (+ end) of the filaments.
Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. [ 5 ] [ 6 ] [ 7 ] In humans it is coded for by the MYO5A gene .
Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans. [5] [6] [7] [8]Recent evidence suggests that Myosin-Vb is related to the creation of memories [9] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.
Myosin II is an elongated protein that is formed from two heavy chains with motor heads and two light chains. Each myosin head contains actin and ATP binding site. The myosin heads bind and hydrolyze ATP, which provides the energy to walk toward the plus end of an actin filament. Myosin II are also vital in the process of cell division. For ...
Myosin V is activated by binding to various cargo receptors on organelles, and then moves along an actin filament towards the (+) end, pulling its cargo along with it. [ 69 ] These nonconventional myosins use ATP hydrolysis to transport cargo, such as vesicles and organelles, in a directed fashion much faster than diffusion.
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. [ 5 ] [ 6 ] This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle ( MYLPF ), smooth muscle ( MYL12B ) and cardiac atrial ...
Initially designated 'intermediate' because their average diameter (10 nm) is between those of narrower microfilaments (actin) and wider myosin filaments found in muscle cells, the diameter of intermediate filaments is now commonly compared to actin microfilaments (7 nm) and microtubules (25 nm).
544791 Ensembl ENSG00000006788 ENSMUSG00000060180 UniProt Q9UKX3 n/a RefSeq (mRNA) NM_003802 NM_001081250 RefSeq (protein) NP_003793 n/a Location (UCSC) Chr 17: 10.3 – 10.37 Mb Chr 11: 67.21 – 67.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene. Function MYH13 is a myosin ...