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  2. Targeted covalent inhibitors - Wikipedia

    en.wikipedia.org/wiki/Targeted_covalent_inhibitors

    Targeted covalent inhibitors (TCIs) or Targeted covalent drugs are rationally designed inhibitors that bind and then bond to their target proteins.These inhibitors possess a bond-forming functional group of low chemical reactivity that, following binding to the target protein, is positioned to react rapidly with a proximate nucleophilic residue at the target site to form a bond.

  3. Clopidogrel - Wikipedia

    en.wikipedia.org/wiki/Clopidogrel

    Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). [10] It is taken by mouth. [10]

  4. Adenosine diphosphate receptor inhibitor - Wikipedia

    en.wikipedia.org/wiki/Adenosine_diphosphate...

    All proton pump inhibitors except for rabeprazole and pantoprazole are metabolized by the hepatic CYP450 enzyme and therefore, may interact with the metabolism of clopidogrel. Omeprazole is considered to have higher potential for drug-drug interaction than other protein pump inhibitors because it is a CYP2C19 inhibitor.

  5. Cyclooxygenase-2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/Cyclooxygenase-2_inhibitor

    The existing nonsteroidal anti-inflammatory drugs differ in their relative specificities for COX-2 and COX-1; while aspirin and ibuprofen inhibit COX-2 and COX-1 enzymes, other NSAIDs appear to have partial COX-2 specificity, particularly meloxicam . [39] Aspirin is ≈170-fold more potent in inhibiting COX-1 than COX-2. [40]

  6. Meloxicam - Wikipedia

    en.wikipedia.org/wiki/Meloxicam

    Meloxicam has been shown, especially at low therapeutic doses, to selectively inhibit COX-2 over COX-1. [8] Meloxicam concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid compared to plasma.

  7. Living longer, not healthier: Study finds periods of poor ...

    www.aol.com/living-longer-not-healthier-study...

    A study led by Mayo Clinic found a “widening gap between lifespan and healthspan" among 183 countries. The lead researcher and another doctor discuss the drivers of poor health late in life.

  8. Parecoxib - Wikipedia

    en.wikipedia.org/wiki/Parecoxib

    In 2005, the US Food and Drug Administration (FDA) issued a letter of non-approval for parecoxib in the United States. No reasons were ever documented publicly for the non-approval, although one study noted increased occurrences of heart attacks following cardiac bypass surgery compared to placebo when high doses of parecoxib were used to control pain after surgery.

  9. The Hardest Working Royal of 2024 Is... - AOL

    www.aol.com/lifestyle/hardest-working-royal-2024...

    Yui Mok - WPA Pool/Getty Images. Princess Anne secured the top spot, yet again, with 217 royal engagements and a 2.4% increase from 2023, according to the report.November was her busiest month ...