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An elevated MSAFP measured at 16–18 weeks gestation is a good predictor of open neural tube defects, however the test has a very high false positive rate, (2% of all women tested in Ontario, Canada between 1993 and 2000 tested positive without having an open neural tube defect, although 5% is the commonly quoted result worldwide) and only a ...
P. Erdinçler, et al. suggests from their findings that the cause of the anomaly is actually a defect in the occipital bone and rachischisis of the posterior vertebral arches leading to herniation of neural tissue through the opening in the bone during gestation. [3]
Research has shown the lack of folic acid (folate) is a contributing factor in the pathogenesis of neural tube defects, including spina bifida. Supplementation of the mother's diet with folate can reduce the incidence of neural tube defects by about 70%, and can also decrease the severity of these defects when they occur.
The posterior arch forms about two-fifths of the circumference of the ring: it ends behind in the posterior tubercle, which is the rudiment of a spinous process and gives origin to the recti capitis posteriores minores and the ligamentum nuchae. The diminutive size of this process prevents any interference with the movements between the atlas ...
The defect can be located anywhere from the cervical region to the sacrum, or through the entire length of the spine. Typical defects are clefts or splits that open the spine to the exterior environment. Rachischisis occurs around 3–4 weeks after conception when the posterior neuropore of the neural tube does not close completely. It is a ...
The front surface of the anterior arch is convex and its anterior tubercle gives attachment to the longus colli muscle. The posterior tubercle is a rudimentary spinous process and gives attachment to the rectus capitis posterior minor muscle. The spinous process is small so as not to interfere with the movement between the atlas and the skull.
Spondylolisthesis is when one spinal vertebra slips out of place compared to another. [1] While some medical dictionaries define spondylolisthesis specifically as the forward or anterior displacement of a vertebra over the vertebra inferior to it (or the sacrum), [2] [3] it is often defined in medical textbooks as displacement in any direction.
The neural arch leans anteriorly at 35° and there are broad areas of featureless bone on the lateral surfaces of the arch. The neural canal is large and teardrop-shaped anteriorly but small and circular at its posterior opening. The various bony struts and sheets that make up the arch have a distinctive configuration. [2]