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PCB warning label on a power transformer known to contain PCBs. Polychlorinated biphenyls (PCBs) are organochlorine compounds with the formula C 12 H 10−x Cl x; they were once widely used in the manufacture of carbonless copy paper, as heat transfer fluids, and as dielectric and coolant fluids for electrical equipment. [2]
Exposure to the coplanar stereoisomer 3,3',4,4',5,5'-hexabromobiphenyl (but not the non-coplanar stereoisomer) in genetically susceptible mice is known to cause immunotoxicity and disorders related to the central nervous system, and even at doses as low as 2.5 mg/kg, excess neonatal fatalities are observed (LD 50 is from 5–10 mg/kg). [1]
Phencyclidine or phenylcyclohexyl piperidine (PCP), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects.
Results for some building materials showed the presence of Aroclor 1262, a specific PCB mixture produced by Monsanto, ... For example, duct insulation in room 520E was found to have Aroclor 1262 ...
For example, 2,3,7,8-tetrachlorodibenzofuran ... PCBs, and other organochlorides, or of non-chlorine containing products in the presence of chlorine donors. [1] ...
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
A group of carcinogenic organic compounds, polychlorinated biphenyls (PCBs), is an example of a congener grouping. The number and locations of Cl groups can vary. In chemistry, congeners are chemical substances "related to each other by origin, structure, or function". [1]
Polychlorinated biphenyls (PCBs) were once commonly used electrical insulators and heat transfer agents. Their use has generally been phased out due to health concerns. PCBs were replaced by polybrominated diphenyl ethers (PBDEs), which bring similar toxicity and bioaccumulation concerns. [citation needed]