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1944 – streptomycin, the first aminoglycoside [2] 1947 – sulfadiazine; 1948 – chlortetracycline, the first tetracycline; 1949 – chloramphenicol, the first amphenicol [2] 1949 – neomycin; 1950 – oxytetracycline; 1950 – penicillin G procaine; 1952 – erythromycin, the first macrolide [2] 1954 – benzathine penicillin; 1955 ...
Plague (Yersinia pestis): Has historically been used as the first-line treatment. However streptomycin is approved for this purpose only by the US Food and Drug Administration. [medical citation needed] In veterinary medicine, streptomycin is the first-line antibiotic for use against gram negative bacteria in large animals (horses, cattle ...
Streptomycin is noteworthy because it is the first significant antibiotic discovered after penicillin, the first systemic antibiotic discovered in America, the first antibiotic active against tuberculosis, and the first-line treatment for plague.
However, these classifications are based on laboratory behavior. The development of antibiotics has had a profound effect on the health of people for many years. Also, both people and animals have used antibiotics to treat infections and diseases. In practice, both treat bacterial infections. [1]
Streptomycin was the first effective drug against gram-negative bacteria [3] and the first antibiotic used to cure tuberculosis. Waksman is credited with coining the term antibiotics to describe antibacterials derived from other living organisms, for example penicillin , though the term was used by the French dermatologist François Henri ...
Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class.
The first members of the tetracycline group to be described were chlortetracycline and oxytetracycline. [ 2 ] [ 40 ] Chlortetracycline (Aureomycin) was first discovered as an ordinary item in 1945 and initially endorsed in 1948 [ 41 ] by Benjamin Minge Duggar , a 73-year-old emeritus professor of botany employed by American Cyanamid – Lederle ...
The first individual treated was a 21-year-old girl who had advanced pulmonary tuberculosis and was given streptomycin on 20 November 1944. [27] By 1946, experiments conducted under the projects of Merck in the UK and USA had proven streptomycin's effectiveness against TB, bubonic plague , cholera, typhoid fever, and other penicillin-resistant ...