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  2. Sirtuin 4 - Wikipedia

    en.wikipedia.org/wiki/Sirtuin_4

    SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity, thereby downregulating insulin secretion in response to amino acids. [7] A deacetylation of malonyl-CoA decarboxylase enzyme by SIRT4 represses the enzyme activity, inhibiting fatty acid oxidation in muscle and liver cells.

  3. Sirtuin - Wikipedia

    en.wikipedia.org/wiki/Sirtuin

    SIRT3, a mitochondrial protein deacetylase, plays a role in the regulation of multiple metabolic proteins like isocitrate dehydrogenase of the TCA cycle. It also plays a role in skeletal muscle as a metabolic adaptive response. Since glutamine is a source of a-ketoglutarate used to replenish the TCA cycle, SIRT4 is involved in glutamine metabolism.

  4. Glutamate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Glutamate_dehydrogenase

    SIRT4 is necessary to regulate the metabolism of amino acids as a method of controlling insulin secretion and regulating blood glucose levels. Bovine liver glutamate dehydrogenase was found to be regulated by nucleotides in the late 1950s and early 1960s by Carl Frieden.

  5. Selenocysteine - Wikipedia

    en.wikipedia.org/wiki/Selenocysteine

    Like other natural proteinogenic amino acids, cysteine and selenocysteine have L chirality in the older D / L notation based on homology to D - and L-glyceraldehyde. In the newer R / S system of designating chirality, based on the atomic numbers of atoms near the asymmetric carbon, they have R chirality, because of the presence of sulfur or ...

  6. α-Amanitin - Wikipedia

    en.wikipedia.org/wiki/Α-amanitin

    α-Amanitin (alpha-Amanitin) is a cyclic peptide of eight amino acids.It is possibly the most deadly of all the amatoxins, toxins found in several species of the mushroom genus Amanita, one being the death cap (Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera.

  7. AOL Mail for Verizon Customers - AOL Help

    help.aol.com/products/aol-mail-verizon

    AOL Mail welcomes Verizon customers to our safe and delightful email experience!

  8. Pore-forming toxin - Wikipedia

    en.wikipedia.org/wiki/Pore-forming_toxin

    The partner proteins in these combinations may belong to different structural groups, depending on the individual toxin: two Toxin_10 proteins (BinA and BinB) act together in the Bin mosquitocidal toxin of Lysinibacillus sphaericus; [14] the Toxin_10 Cry49 is co-dependent on the 3-domain toxin family member Cry48 for its activity against Culex ...

  9. Bronze Age mass grave reveals grisly massacre in which ...

    www.aol.com/news/bronze-age-mass-grave-reveals...

    For example, DNA and RNA are made from “right-handed” nucleotides, and proteins are made from “left-handed” amino acids. Just as a right-handed glove cannot fit a left hand, interactions ...