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M2-PK, as measured in feces, is a potential tumor marker for colorectal cancer. When measured in feces with a cutoff value of 4 U/ml, its sensitivity has been estimated to be 85% (with a 95% confidence interval of 65 to 96%) for colon cancer and 56% (confidence interval 41–74%) for rectal cancer. [1] Its specificity is 95%. [2]
The gold standard of early detection of colon polyp/cancer is the invasive colonoscopy, but with high expense about $557, while tumor marker M2-PK Test expense only about $15-$25. The invasive colonoscopy makes acceptance of it low among patients, so relatively cheap non-invasive M2-PK Test is a good choice for detection early polyp/cancer. [2]
For example, tumor markers like Ki-67 can be used to choose form of treatment or in prognostics but are not useful to give a diagnosis, while other tumor markers have the opposite functionality. Therefore it's important to follow the guidelines of the specific tumor marker. Tumor markers are mainly used in clinical medicine to support a ...
Doctors and advocates have been waiting for years for a new blood-based DNA test for colon cancer. Promising results released by the New England Journal of Medicine show the promise of a cell-free ...
This provocative study demonstrates that biological age, which can be evaluated by a blood test, is associated with a higher incidence of precancerous colon polyps.” — Anton Bilchik, MD, PhD ...
The blood test is tuned to pick up the signature of colon cancer but more research is needed to determine if it might pick up other cancers as well and give misleading results, Corley said.
The CEA blood test is not reliable for diagnosing cancer or as a screening test for early detection of cancer. [8] Most types of cancer do not result in a high CEA level. [9] Serum from individuals with colorectal carcinoma often has higher levels of CEA than healthy individuals (above approximately 2.5ng/mL). [10]
Another colon cancer screening method includes fecal occult blood tests that detect blood in the stool, which can be a warning sign of colon polyps or cancer. The FIT-DNA tests, such as Cologuard ...
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