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Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, [1] is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time.
The presentation depends if it is mycosis fungoides or Sézary syndrome, the most common, though not the only types. Among the symptoms for the aforementioned types are: enlarged lymph nodes, an enlarged liver and spleen, and non-specific dermatitis. [1]
Sézary disease and mycosis fungoides are cutaneous T-cell lymphomas having a primary manifestation in the skin. [5] The disease's origin is a peripheral CD4+ T-lymphocyte, [3] although rarer CD8+/CD4- cases have been observed. [3]
The following is a list of cancer types. Cancer is a group of diseases that involve abnormal increases in the number of cells , with the potential to invade or spread to other parts of the body. [ 1 ]
Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis.The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow.
Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's T-cells [1] [2] [3] caused by human T cell leukemia/lymphotropic virus type 1 (). [4] All ATL cells contain integrated HTLV-1 provirus further supporting that causal role of the virus in the cause of the neoplasm. [4]
The premycotic phase is a phase of mycosis fungoides in which a patient has areas of red, scaly, itchy skin on areas of the body that are usually not exposed to sun. This is early-phase mycosis fungoides, but it is hard to diagnose the rash as mycosis fungoides during this phase. The premycotic phase may last from months to decades.
pcALCL is the second most common lymphoma [16] in the category of Cutaneous T cell lymphoma cutaneous T cell lymphomas [24] that includes lymphomatoid papulosis, various borderline CD30-positive cutaneous T cell lymphomas, [9] and mycosis fungoides. [16] The median age at diagnosis for pcALC is 61 years.