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Not all select agents require BSL-4 handling, namely select bacteria and toxins, but most select agent viruses do (with the notable exception of SARS-CoV-1 which can be handled in BSL3). Many non-select agent viruses are often handled in BSL-4 according to facility SOPs or when dealing with new viruses closely related to viruses that require BSL-4.
In epidemiology, force of infection (denoted ) is the rate at which susceptible individuals acquire an infectious disease. [1] Because it takes account of susceptibility it can be used to compare the rate of transmission between different groups of the population for the same infectious disease, or even between different infectious diseases.
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.. Infection – transmission, entry/invasion after evading/overcoming defense, establishment, and replication of disease-causing microscopic organisms (pathogens) inside a host organism, and the reaction of host tissues to them and to the toxins they produce.
Almost all fungal infections are sapronoses, [1] but there are no known sapronotic viruses. [2] Occupation often plays a role in sapronoses: people working with the soil, such as farmers or gardeners, are often at particularly high risk. [3] Sporotrichosis, a fungal sapronosis, is for example sometimes known as "rose handler's disease". [4]
Water is one of the agents of deterioration. Its effects can be seen in these flood-damaged library books. The 'ten agents of deterioration' are a conceptual framework developed by the Canadian Conservation Institute (CCI) used to categorise the major causes of change, loss or damage to cultural heritage objects (such as collections held by galleries, libraries, archives and museums). [1]
The universal stress protein (USP) domain is a superfamily of conserved genes which can be found in bacteria, archaea, fungi, protozoa and plants. [2] Proteins containing the domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics and metals.
The Agents of Deterioration are the ten primary sources of damage to heritage objects and buildings comprised in a comprehensive list by the Canadian Conservation Institute. The Agents are physical forces, fire, pests, light (ultraviolet and infrared), incorrect relative humidity, thieves and vandals, water, pollutants, incorrect temperature ...
The resistome was first used to describe the resistance capabilities of bacteria preventing the effectiveness of antibiotics . [4] [5] Although antibiotics and their accompanying antibiotic resistant genes come from natural habitats, before next-generation sequencing, most studies of antibiotic resistance had been confined to the laboratory. [6]