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Nanocrystals used for drug delivery can increase saturation solubility and dispersion velocity. Generally, saturation solubility is thought to be a function of temperature, but it is also based on other factors, such as crystalline structure and particle size, in regards to nanocrystals. The Ostwald-Freundlich equation below shows this ...
Micropore particle technology consists of fine, highly porous particles that remove fluid by a combination of capillary action and evaporation. [1] [2] Currently, they are mainly used in wound healing, where they absorb wound exudate into their micropore structure. Here capillary flow transports the exudate away from the wound surface towards ...
Clinically, the particle size of a drug can affect its release from dosage forms that are administered orally, parenterally, rectally and topically. The successful formulation of suspensions, emulsions and tablets; both physical stability and pharmacological response also depends on the particle size achieved in the product. [2] [3] [4] [5]
A study by the European Environment Agency estimates that 307,000 people have died prematurely in 2019 due to fine particle pollution in the 27 EU member states. [214] A study in 2000 conducted in the U.S. explored how fine particulate matter may be more harmful than coarse particulate matter. The study was based on six different cities.
The lung deposition characteristics and efficacy of an aerosol depend largely on the particle or droplet size. Generally, the smaller the particle the greater its chance of peripheral penetration and retention. However, for very fine particles below 0.5 μm in diameter there is a chance of avoiding deposition altogether and being exhaled.
The drug can be released by a pH change. Second, mesoporous silica coated UCNPs can be used, where drugs can be stored and released from the porous surface. Thirdly, the drug can be encapsulated and transferred in a hollow UCNP shell. [34] Light-activated processes that deliver or activate medicine are known as photodynamic therapeutic (PDT).
The tiny pollutants emitted by fossil fuel combustion and wildfires may be raising the risk of adverse birth outcomes, a study has found. Exposure to fine particulate matter (PM 2.5) can cause ...
Polystyrene integrated solid foams are not commonly used in biomedical applications but have shown promise as a new drug delivery vehicle. The manipulation of the porous foam networks is a fundamental component in solid foam dosing – affecting variables such as dissolution, adsorption, and drug diffusion. [4]