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Other causes of peptic ulcer disease include gastric ischaemia, drugs, metabolic disturbances, cytomegalovirus (CMV), upper abdominal radiotherapy, Crohn's disease, and vasculitis. [16] Gastrinomas ( Zollinger–Ellison syndrome ), or rare gastrin-secreting tumors, also cause multiple and difficult-to-heal ulcers.
This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by H. pylori. In 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery that peptic ulcer disease (PUD) was primarily caused by Helicobacter pylori , a bacterium with affinity ...
Zollinger-Ellison syndrome (ZES) is caused by a gastrinoma, which is a gastrin-producing tumor that causes gastric acid hypersecretion. [11] The main clinical manifestations of ZES are peptic ulcers and diarrhea. [12] The initial diagnostic test for ZES is a fasting serum gastrin level when antisecretory medications are stopped. If the gastrin ...
What Causes Stomach Ulcers? “A peptic ulcer is a sore or a break in the tissue that lines your stomach or small intestine,” explains Dr. Leah DeCoste, MD , a gastroenterologist with Gastro ...
Peptic ulcer disease, a wearing away of the stomach lining, can be asymptomatic in some cases, but others are severe enough to make a patient double over in pain, two doctors said.
Peptic ulcers are a consequence of inflammation that allows stomach acid and the digestive enzyme pepsin to overwhelm the protective mechanisms of the mucous membranes. The location of colonization of H. pylori, which affects the location of the ulcer, depends on the acidity of the stomach. [49]
Upper gastrointestinal bleeding can be caused by peptic ulcers, gastric erosions, esophageal varices, and rarer causes such as gastric cancer. The initial assessment includes measurement of the blood pressure and heart rate, as well as blood tests to determine the hemoglobin.
The causes are divided into benign or malignant. Benign Peptic ulcer disease; Infections, such as tuberculosis; and infiltrative diseases, such as amyloidosis.; A rare cause of gastric outlet obstruction is blockage with a gallstone, also termed "Bouveret syndrome" or "Bouveret's syndrome".
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