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Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. [5] It is an important regulator of cardiac development [ 6 ] and a marker of hippocampal neural stem cells . [ 7 ] [ 8 ]
Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [5]
The protein kinase domain is 330 amino acids long and is located near the N-terminus of the protein. [ 23 ] [ 24 ] In addition to its kinase domain, HIPK2 has two nuclear localization signals, [ 25 ] a SUMO interaction motif, [ 25 ] an auto-inhibitory domain [ 23 ] a transcriptional co-repression domain, [ 13 ] and several interaction domains ...
A hip labral tear is characterized by damage to cartilage surrounding the outer rim of the hip joint. Some studies suggest that hip labral tears could be the reason for up to 55 percent of cases ...
In molecular biology, the engrailed homeobox proteins are a family of homeobox proteins which are characterised by the presence of a region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain.
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. [5] This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells.