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A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al. through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old caucasian male. [1]
A549 cells – derived from a cancer patient lung tumor; HeLa cells – a widely used human cell line isolated from cervical cancer patient Henrietta Lacks; HEK 293 cells – derived from human fetal cells; Huh7 cells – hepatocyte-derived carcinoma cell line; Jurkat cells – a human T lymphocyte cell line isolated from a case of leukemia
A549 cells share the same characteristics with the alveolar type II cells. This are type II pneumocytes crucial for lung homeostasis, and regeneration upon damage. For research purposes to unravel different molecular mechanisms leading to lung diseases, A549 cells serves as a good model to which translational research can be relied upon.
The story of how the HeLa cell line came to be was also the subject of a 2010 episode of the podcast Radiolab. [69] HeLa cells were the subject of a 2010 book by Rebecca Skloot, The Immortal Life of Henrietta Lacks, investigating the historical context of the cell line and how the Lacks family was involved in its use. [14]
To further confirm that endogenous wild-type p53 is really causing the repression of survivin gene expression, the authors induced A549 (human lung cancer cell line with wild-type p53) and T47D (human breast cancer cell line with mutant p53) cells with DNA-damaging agent adriamycin to trigger the physiological p53 apoptotic response in these ...
In Klein’s case, a Postal Service spokeswoman said, the problem is the road. Hillman Ridge is paved but narrows to a width slightly larger than a pickup truck as it approaches Klein’s property.
The control group in Tuesday's release, which excludes several volatile categories and factors into the gross domestic product reading for the quarter, increased by 0.4%, in line with estimates.
The U.S. House of Representatives is expected to consider on Thursday what to do with a report on alleged sexual misconduct and drug use by ex-congressman Matt Gaetz, who has dropped his bid to ...
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