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Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. [7] It is administered intravenously (injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus. [8]
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
Upon presence of infection, it can be considered as therapeutic puncture. [2] Often, multiple repeated lavages are subsequently required to allow for full washout of infection. In contemporary practice, endoscopic sinus surgery has largely replaced antral lavage and as such, it is rarely performed.
The antimicrobial spectrum of an antibiotic can be determined by testing its antimicrobial activity against a wide range of microbes in vitro. Nonetheless, the range of microorganisms which an antibiotic can kill or inhibit in vivo may not always be the same as the antimicrobial spectrum based on data collected in vitro. [2] [5]
Treatments for sinusitis [70] [71] Treatment Indication Rationale Time Viral and some bacterial sinusitis Sinusitis is usually caused by a virus which is not affected by antibiotics. [70] Antibiotics Bacterial sinusitis Cases accompanied by extreme pain, skin infection, or which last a long time may be caused by bacteria. [70] Nasal irrigation
This treatment is considered minimally invasive and joint sparing. [3] Complications associated with subtalar arthroereisis include undercorrection (due to the use of undersized implants), sinus tarsi pain, and implant extrusion. Less common complications include overcorrection caused by oversized implants, synovitis, infection, and peroneal spasm.
Once a specific resistance profile has been isolated via clinical laboratory findings, treatment is often modified as indicated. Vancomycin has long been considered a drug of last resort, due to its efficiency in treating multiple drug-resistant infectious agents and the requirement for intravenous administration.
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
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