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Conventional DMARDs are known to be the first-line treatment for rheumatoid arthritis. [9] Treatment can be a monotherapy or in combination with other anti-arthritic medications. Common DMARDs include oral methotrexate, leflunomide, or sulfasalazine. Conventional DMARDs have a slow onset of action and can take 2–3 months to exhibit effect. [9]
Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
Agents may be used in combination, however, people may experience greater side effects. [8] [122] Methotrexate is the most important and useful DMARD and is usually the first treatment. [8] [5] [123] A combined approach with methotrexate and biologics improves ACR50, HAQ scores and RA remission rates.
For some types of mild to moderate arthritis, OTC medications can help ease pain. This includes acetaminophen (Tylenol®) and nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen (Advil ...
With an estimated 52.5 million adults in the U.S. affected by arthritis alone and up to 24% of adults experiencing muscle pain during their lifetime, effective topical pain relievers can be life ...
Side effects: Side effects are possible with any medication, including topical pain relievers. Ahmad says the most common side effect is skin irritation, which certain ingredients or preservatives ...
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