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The WHO states praziquantel is safe during pregnancy (although does not recommend use during the first trimester). [ 22 ] [ 23 ] Animal studies have failed to reveal evidence of fetal harm. Praziquantel is effective in reducing schistosomiasis during pregnancy. [ 24 ]
While it does not appear to be harmful during pregnancy, it has not been studied for this use. [3] It is unclear if it is safe for use during breastfeeding. [2] It is in the antihelmintic family of medications. [4] It works by paralyzing worms. [4] Pyrantel was initially described in 1965. [5]
Praziquantel, however, is often the preferred treatment. [2] It is given by mouth and used as a single dose. [2] Common side effects include sleepiness, headache, nausea, diarrhea, and reddish urine. [1] It is typically not recommended during pregnancy, if possible. [1] Seizures may occur and therefore caution is recommended in people with ...
Praziquantel can be safely used in pregnant women and young children. [26] The treatment objective is to cure the disease and to prevent the evolution of the acute to the chronic form of the disease. All cases of suspected schistosomiasis should be treated regardless of presentation because the adult parasite can live in the host for years.
Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, and is a medication which is currently under investigation for the treatment of schistosomiasis in young children since it has less side effects than the usual racemic mixture formulation of praziquantel.
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In fact, in 2002, the World Health Organization recommended the use of Praziquantel in pregnant and lactating women, though controlled trials are still needed to verify this. Another possible drug option is Tetrachloroethylene, a chlorinated hydrocarbon, but its use has been superseded by new antihelminthic drugs (like Praziquantel). A 1978 ...