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Praziquantel is well absorbed (about 80%) from the gastrointestinal tract. However, due to extensive first-pass metabolism, only a relatively small amount enters systemic circulation. Praziquantel has a serum half-life of 0.8 to 1.5 hours in adults with normal renal and liver function. Metabolites have a half-life of 4 to 5 hours.
Niclosamide (for tapeworm infections) Praziquantel (for tapeworm infections) Albendazole (broad spectrum) Antitrematodes [Praziquantel] Antiamoebics. Rifampin;
The standard treatment for diphyllobothriasis (as well as many other tapeworm infections) is a single dose of praziquantel, 5–10 mg/kg orally once for both adults and children. [16] [17] [18] Praziquantel is not FDA-approved for this indication. [16] Praziquantel has few side effects, many of which are similar to the symptoms of ...
Anthelmintic resistance in parasites is widespread; drug resistance exists in all livestock hosts and to all anthelmintic drug classes. [13] This is a major threat to the sustainability of modern ruminant livestock production, resulting in reduced productivity, compromised animal health and welfare, [ 12 ] and increased greenhouse gas emissions ...
Since most tapeworm infections within the genus Spirometra have similar egg morphology, species characterization is not typical. Animals are usually treated with anti-worm medications, such as Praziquantel. [10] Surgical removal is the most common treatment in humans, as well as treatment by anti-worm medication such as Albendazole. [11]
[56] Albendazole is also a viable (and potentially superior) drug for the disease, and it has a lower cost and fewer drug interactions than praziquantel. [57] [58] In more complex situations, a combination of praziquantel, albendazole and steroids (such as corticosteroids to reduce the inflammation) is recommended. [59]
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
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