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Diarrhea is a well-known side effect of metformin. Learn more about why this gut-related side effect happens and how to manage it. Diarrhea is a well-known side effect of metformin. Learn more ...
The most common side effects of metformin include: Diarrhea. Nausea. Vomiting. Upset stomach. Weakness. A metallic taste in your mouth.
Metformin inhibits cyclic AMP production, blocking the action of glucagon, and thereby reducing fasting glucose levels. [116] Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice, and this may contribute to its mode of action possibly through an effect on glucagon-like peptide-1 secretion. [107]
A smaller study on metformin also found that the average weight lost in 154 patients was between 5.6 and 7 kilograms — or 13 to 15 pounds. ... Diarrhea. Abdominal pain. Nausea.
Vildagliptin/metformin is indicated in the treatment of type-2 diabetes mellitus: [4] [6] [7] it is indicated in the treatment of adults who are unable to achieve sufficient glycaemic control at their maximally tolerated dose of oral metformin alone or who are already treated with the combination of vildagliptin and metformin as separate tablets.
In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...
Though it’s considered safe, up to 30 percent of people who take metformin experience gastrointestinal side effects like nausea, vomiting, and diarrhea. Naltrexone-bupropion .
The most common side-effects are upper respiratory tract infection, diarrhea, combined edema/peripheral edema and headache, respectively. Most clinical adverse events were similar between groups treated with pioglitazone in combination with metformin and those treated with pioglitazone monotherapy. [medical citation needed]
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