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Chronic sclerosing sialadenitis is a chronic (long-lasting) inflammatory condition affecting the salivary gland. Relatively rare in occurrence, this condition is benign, but presents as hard, indurated and enlarged masses that are clinically indistinguishable from salivary gland neoplasms or tumors.
Salivary gland diseases (SGDs) are multiple and varied in cause. [1] There are three paired major salivary glands in humans: the parotid glands, the submandibular glands, and the sublingual glands. There are also about 800–1,000 minor salivary glands in the mucosa of the mouth.
Sialolithiasis accounts for about 50% of all disease occurring in major salivary glands, and for about 66% of all obstructive salivary gland diseases. Salivary gland stones are twice as common in males as in females. The most common age range in which they occur is between 30 and 60, and they are uncommon in children. [2]
Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common being the parotid gland, followed by submandibular and sublingual glands. [1] It should not be confused with sialadenosis (sialosis) which is a non-inflammatory enlargement of the major salivary glands.
The Stafne defect (also termed Stafne's idiopathic bone cavity, Stafne bone cavity, Stafne bone cyst (misnomer), lingual mandibular salivary gland depression, lingual mandibular cortical defect, latent bone cyst, or static bone cyst) is a depression of the mandible, most commonly located on the lingual surface (the side nearest the tongue).
Strictures are the second most common cause of chronic obstructive sialadenitis, after salivary stones. [1] In line with this, strictures may give rise to the "meal time syndrome", [1] where there is pain and swelling of the involved salivary gland upon salivary stimulation with the sight, smell and taste of food.
Sjögren's syndrome: Chronic inflammation of the salivary glands may also be an autoimmune disease known as Sjögren's syndrome. The disease most commonly appears in people aged 40–60 years, but it may affect small children. In Sjögren syndrome, the prevalence of parotitis in women versus men is approximately 9:1.
However, the condition may arise anywhere minor salivary glands are located. [nb 1] It has also been occasionally reported to involve the major salivary glands. [2] [3] It may be present only on one side, or both sides. [1] The lesion typically is 1–4 cm in diameter. [4] Initially, the lesion is a tender, erythematous (red) swelling. Later ...