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ISGs are genes whose expression can be stimulated by interferon, but may also be stimulated by other pathways. [1] Interferons are a type of protein called a cytokine, which is produced in response to infection. [9] When released, they signal to infected cells and other nearby cells that a pathogen is present. [9]
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [ 5 ] [ 6 ] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier.
[29] [30] [31] The ability of interferon to induce protein production from interferon stimulated genes (ISGs) can also be affected. Production of protein kinase R, for example, can be disrupted in cells infected with JEV. [26] Some viruses escape the anti-viral activities of interferons by gene (and thus protein) mutation.
Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). [1] These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated.
Gene ontology; Molecular function ... Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene. [5] [6] [7] References
As the foundation of our cells, protein plays a role in every single function of the body, with a particularly vital role in immune health, muscle development and bone density, to name a few ...
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. [ 5 ] STING plays an important role in innate immunity .
The diagnosis "is the result of a gene mutation that disproportionately affects those of Asian descent, particularly women." “About 50% of nonsmoker Asians [with lung cancer] ...