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Dilution has been used as a method to grow and identify bacteria since the 1870s, and as a method of testing the susceptibility of bacteria to antibiotics since 1929, also by Alexander Fleming. [25] The way of determining susceptibility changed from how turbid the solution was, to the pH (in 1942), to optical instruments. [25]
The disk diffusion test (also known as the agar diffusion test, Kirby–Bauer test, disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test and KB test) is a culture-based microbiology assay used in diagnostic and drug discovery laboratories. In diagnostic labs, the assay is used to determine the susceptibility ...
Nowadays, the MIC is used in antimicrobial susceptibility testing. The MIC is reported by providing the susceptibility interpretation next to each antibiotic. The different susceptibility interpretations are: "S" (susceptible or responding to a standard dosing regimen), "I" (intermediate or requiring increased exposure), and "R" (resistant).
Broth microdilution is also highly accurate. The accuracy of its results are comparable to agar dilution, the gold standard of susceptibility testing. Other advantages include the commercial availability of plates, the ease of testing and storing the plates, and the ability for the results of some tests to be read by machines. [1]
Etest and related instruments offer one of the most efficient methods for generating on-scale MIC values across 15 doubling dilutions for susceptibility testing of a wide range of drug-bug combinations, including fastidious organisms. Simplex C76 automates the placement of 1 to 6 different Etest strips to simplify the setup of MIC panels ...
Agar dilution is one of two methods (along with broth dilution) used by researchers to determine the minimum inhibitory concentration (MIC) of antibiotics. It is the dilution method most frequently used to test the effectiveness of new antibiotics when a few antibiotics are tested against a large panel of different bacteria.
An example of such testing is antibiotic susceptibility testing by measurement of minimum inhibitory concentration which is routinely used in medical microbiology and research. If a suspension used is too heavy or too dilute, an erroneous result (either falsely resistant or falsely susceptible) for any given antimicrobial agent could occur.
The Microscopic Observation Drug Susceptibility assay (MODS) is a culture method shown to be more sensitive, faster and cheaper test than current culture-based tests for Tuberculosis. The Microscopic Observation Drug Susceptibility assay (MODS) involves direct observation of Mycobacterium tuberculosis and simultaneously yields drug-resistance.
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